Ontology highlight
ABSTRACT:
SUBMITTER: Muthu P
PROVIDER: S-EPMC3236635 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Muthu Priya P Wang Li L Yuan Chen-Ching CC Kazmierczak Katarzyna K Huang Wenrui W Hernandez Olga M OM Kawai Masataka M Irving Thomas C TC Szczesna-Cordary Danuta D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110901 12
The myosin essential light chain (ELC) is a structural component of the actomyosin cross-bridge, but its function is poorly understood, especially the role of the cardiac specific N-terminal extension in modulating actomyosin interaction. Here, we generated transgenic (Tg) mice expressing the A57G (alanine to glycine) mutation in the cardiac ELC known to cause familial hypertrophic cardiomyopathy (FHC). The function of the ELC N-terminal extension was investigated with the Tg-Δ43 mouse model, wh ...[more]