Dataset Information

Stressful Effects of Individual and Combined Exposure to Low-Concentration Polylactic Acid Microplastics and Chromium on Marine Medaka Larvae (Oryzias melastigma).

ABSTRACT: Microplastics and heavy metal pollution frequently co-occur in the marine environment, raising concerns about their potentially harmful impacts on marine fish. This study undertook a comprehensive evaluation of the individual and combined stress effects of polylactide microplastics (PLA-MPs) and chromium (Cr) on marine medaka larvae. Following a 14-day exposure to PLA-MPs (100 μg/L) and Cr (50 μg/L), both individually and in combination, significant increases in heart rate and body length were observed. Notably, the combined exposure to PLA-MPs and Cr caused marked histopathological alterations, including shedding, atrophy, and lysis of the intestinal tissues. Furthermore, both individual and combined exposure induced oxidative stress in fish larvae, leading to changes in various enzyme activity indices. Individual exposure to either PLA-MPs or Cr led to anxious behavior in the larvae, whereas combined exposure not only caused anxious behavior but also altered swimming patterns. These findings suggest that combined exposure to PLA-MPs and Cr can exacerbate the toxic effects on marine medaka larvae.

SUBMITTER: Yin Y

PROVIDER: S-EPMC11359823 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Publications

Stressful Effects of Individual and Combined Exposure to Low-Concentration Polylactic Acid Microplastics and Chromium on Marine Medaka Larvae (<i>Oryzias melastigma</i>).

Yin Yuan Y Ma Yini Y Li Qiang Q Chen Nan N Wen Shaobai S

Toxics 20240816 8

Microplastics and heavy metal pollution frequently co-occur in the marine environment, raising concerns about their potentially harmful impacts on marine fish. This study undertook a comprehensive evaluation of the individual and combined stress effects of polylactide microplastics (PLA-MPs) and chromium (Cr) on marine medaka larvae. Following a 14-day exposure to PLA-MPs (100 μg/L) and Cr (50 μg/L), both individually and in combination, significant increases in heart rate and body length were o ...[more]

PMID: 39195695

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Project description:BDE-47 is one of the most widely found congeners of PBDEs in marine environments. The potential immunomodulatory effects of BDE-47 on fish complement system were studied using the marine medaka Oryzias melastigma as a model fish. Three-month-old O. melastigma were subjected to short-term (5 days) and long-term (21 days) exposure to two concentrations of BDE-47 (low dose at 290 ± 172 ng/day; high dose at 580 ± 344 ng/day) via dietary uptake of BDE-47 encapsulated in Artemia nauplii. Body burdens of BDE-47 and other metabolic products were analyzed in the exposed and control fish. Only a small amount of debrominated product, BDE-28, was detected, while other metabolic products were all under detection limit. Transcriptional expression of six major complement system genes involved in complement activation: C1r/s (classical pathway), MBL-2 (lectin pathway), CFP (alternative pathway), F2 (coagulation pathway), C3 (the central component of complement system), and C9 (cell lysis) were quantified in the liver of marine medaka. Endogenous expression of all six complement system genes was found to be higher in males than in females (p < 0.05). Upon dietary exposure of marine medaka to BDE-47, expression of all six complement genes were downregulated in males at day 5 (or longer), whereas in females, MBl-2, CFP, and F2 mRNAs expression were upregulated, but C3 and C9 remained stable with exposure time and dose. A significant negative relationship was found between BDE-47 body burden and mRNA expression of C1r/s, CFP, and C3 in male fish (r = -0.8576 to -0.9447). The above findings on changes in complement gene expression patterns indicate the complement system may be compromised in male O. melastigma upon dietary exposure to BDE-47. Distinct gender difference in expression of six major complement system genes was evident in marine medaka under resting condition and dietary BDE-47 challenge. The immunomodulatory effects of BDE-47 on transcriptional expression of these complement components in marine medaka were likely induced by the parent compound instead of biotransformed products. Our results clearly demonstrate that future direction for fish immunotoxicology and risk assessment of immunosuppressive chemicals must include parallel evaluation for both genders.

Dataset Information

Stressful Effects of Individual and Combined Exposure to Low-Concentration Polylactic Acid Microplastics and Chromium on Marine Medaka Larvae (Oryzias melastigma).

Publications

Stressful Effects of Individual and Combined Exposure to Low-Concentration Polylactic Acid Microplastics and Chromium on Marine Medaka Larvae (<i>Oryzias melastigma</i>).

Similar Datasets

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