Ontology highlight
ABSTRACT:
SUBMITTER: Souza KFCSE
PROVIDER: S-EPMC11360054 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Souza Kauê Francisco Corrêa de Souza E KFCSE Rabelo Vitor Won-Held VW Abreu Paula Alvarez PA Santos Cláudio César Cirne CCC Amaral E Silva Nayane Abreu do NAD Luna Daniela de D Ferreira Vitor Francisco VF Braz Bernardo Ferreira BF Santelli Ricardo Erthal RE Gonçalves-de-Albuquerque Cassiano Felippe CF Paixão Izabel Christina Nunes de Palmer ICNP Burth Patricia P
ACS omega 20240816 34
Since 1970 acyclovir (ACV) has been the reference drug in treating herpes simplex virus (HSV) infections. However, resistant herpes simplex virus type 1 (HSV-1) strains have emerged, narrowing the treatment efficacy. The antiviral activity of classical Na<sup>+</sup>, K<sup>+</sup> ATPase enzyme (NKA) inhibitors linked the viral replication to the NKA's activity. Herein, we evaluated the anti-HSV-1 activity of synthetic naphthoquinones, correlating their antiviral activity with NKA inhibition. W ...[more]