Unknown

Dataset Information

0

The co-chaperone BAG3 regulates Herpes Simplex Virus replication.


ABSTRACT: Viruses as obligate intracellular parasites use host cell proteins to ensure efficient replication and spread. Cellular proteins are required for several stages of a virus life cycle. Here, we identify BAG3, a co-chaperone, as a regulator of herpes virus immediate early gene expression. We report that a herpes simplex virus lacking the gene encoding a potent transcriptional activator, ICP0, is compromised for replication in cells silenced for BAG3 in a multiplicity of infection-dependent manner. We also show a requirement for BAG3 to augment virus gene expression and demonstrate that the co-chaperone acts independently of promyelocytic leukemia to increase herpes simplex virus replication.

SUBMITTER: Kyratsous CA 

PROVIDER: S-EPMC2603433 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8195378 | biostudies-literature
| S-EPMC4249532 | biostudies-literature
| S-EPMC4859661 | biostudies-literature
| PRJNA338711 | ENA
| S-EPMC3196403 | biostudies-literature
| S-EPMC7166384 | biostudies-literature
| S-EPMC5309293 | biostudies-literature
2017-08-30 | GSE95716 | GEO
| S-EPMC4301124 | biostudies-literature
| S-EPMC3201796 | biostudies-literature