Sparks of function by de novo protein design.
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ABSTRACT:
SUBMITTER: Chu AE
PROVIDER: S-EPMC11366440 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Publications
Sparks of function by de novo protein design.
Chu Alexander E AE Lu Tianyu T Huang Po-Ssu PS
Nature biotechnology 20240215 2
Information in proteins flows from sequence to structure to function, with each step causally driven by the preceding one. Protein design is founded on inverting this process: specify a desired function, design a structure executing this function, and find a sequence that folds into this structure. This 'central dogma' underlies nearly all de novo protein-design efforts. Our ability to accomplish these tasks depends on our understanding of protein folding and function and our ability to capture ...[more]
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