Ontology highlight
ABSTRACT:
SUBMITTER: Salihovic A
PROVIDER: S-EPMC11368039 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Chemical science 20240827
Nucleosides are pervasive building blocks that are found throughout nature and used extensively in medicinal chemistry and biotechnology. However, the preparation of base-modified analogues using conventional synthetic methodology poses challenges in scale-up and purification. In this work, an integrated approach involving structural analysis, screening and reaction optimization, is established to prepare 2'-deoxyribonucleoside analogues catalysed by the type II nucleoside 2'-deoxyribosyltransfe ...[more]