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Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor.

ABSTRACT: We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations.

SUBMITTER: Du LH

PROVIDER: S-EPMC9079605 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor.

Du Li-Hua LH Shen Jia-Hong JH Dong Zhen Z Zhou Na-Ni NN Cheng Bing-Zhuo BZ Ou Zhi-Min ZM Luo Xi-Ping XP

RSC advances 20180403 23

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from <i>Thermomyces lanuginosus</i> with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations. ...[more]

PMID: 35541271

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