Ontology highlight
ABSTRACT:
SUBMITTER: Polyzos AA
PROVIDER: S-EPMC11375129 | biostudies-literature | 2024 Sep
REPOSITORIES: biostudies-literature
Polyzos Aris A AA Cheong Ana A Yoo Jung Hyun JH Blagec Lana L Toprani Sneh M SM Nagel Zachary D ZD McMurray Cynthia T CT
Nature communications 20240904 1
We lack the fundamental information needed to understand how DNA damage in the brain is generated and how it is controlled over a lifetime in the absence of replication check points. To address these questions, here, we integrate cell-type and region-specific features of DNA repair activity in the normal brain. The brain has the same repair proteins as other tissues, but normal, canonical repair activity is unequal and is characterized by high base excision repair (BER) and low double strand bre ...[more]