Ontology highlight
ABSTRACT:
SUBMITTER: Connolly BA
PROVIDER: S-EPMC1140638 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Connolly Beth A BA Rice Jared J Feig Larry A LA Buchsbaum Rachel J RJ
Molecular and cellular biology 20050601 11
The exchange factor Tiam1 regulates multiple cellular functions by activating the Rac GTPase. Active Rac has various effects in cells, including alteration of actin cytoskeleton and gene expression, via binding to and modulating the activity of diverse effector proteins. How individual Rac effectors are selected for activation and regulated in response to upstream signals is not well understood. We find that Tiam1 contributes to both of these processes by binding to IRSp53, an adaptor protein th ...[more]