Ontology highlight
ABSTRACT:
SUBMITTER: Huang P
PROVIDER: S-EPMC1142410 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Huang Ping P Altshuller Yelena M YM Hou June Chunqiu JC Pessin Jeffrey E JE Frohman Michael A MA
Molecular biology of the cell 20050316 6
Insulin stimulates glucose uptake in fat and muscle by mobilizing Glut4 glucose transporters from intracellular membrane storage sites to the plasma membrane. This process requires the trafficking of Glut4-containing vesicles toward the cell periphery, docking at exocytic sites, and plasma membrane fusion. We show here that phospholipase D (PLD) production of the lipid phosphatidic acid (PA) is a key event in the fusion process. PLD1 is found on Glut4-containing vesicles, is activated by insulin ...[more]