Ontology highlight
ABSTRACT:
SUBMITTER: Llinas P
PROVIDER: S-EPMC1142576 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Llinas Paola P Le Du Marie Hélène MH Gårdsvoll Henrik H Danø Keld K Ploug Michael M Gilquin Bernard B Stura Enrico A EA Ménez André A
The EMBO journal 20050407 9
We report the crystal structure of a soluble form of human urokinase-type plasminogen activator receptor (uPAR/CD87), which is expressed at the invasive areas of the tumor-stromal microenvironment in many human cancers. The structure was solved at 2.7 A in association with a competitive peptide inhibitor of the urokinase-type plasminogen activator (uPA)-uPAR interaction. uPAR is composed of three consecutive three-finger domains organized in an almost circular manner, which generates both a deep ...[more]