Unknown

Dataset Information

0

Recombinant Newcastle disease virus as a vaccine vector.

ABSTRACT: A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

SUBMITTER: Nakaya T 

PROVIDER: S-EPMC114773 | biostudies-literature | 2001 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Recombinant Newcastle disease virus as a vaccine vector.

Nakaya T T   Cros J J   Park M S MS   Nakaya Y Y   Zheng H H   Sagrera A A   Villar E E   García-Sastre A A   Palese P P  

Journal of virology 20011201 23

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector. ...[more]

Similar Datasets

Unknown Recombinant Newcastle disease virus as a vaccine vector for cancer therapy.
| S-EPMC2878970 | biostudies-other
Unknown Characterization of a recombinant Newcastle disease virus vaccine strain.
| S-EPMC2565930 | biostudies-literature
Unknown Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine.
| S-EPMC5772752 | biostudies-literature
Unknown Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens.
| S-EPMC1887550 | biostudies-literature
Unknown Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt.
| S-EPMC6371441 | biostudies-literature
Unknown Establishing a Robust Manufacturing Platform for Recombinant Veterinary Vaccines: An Adenovirus-Vector Vaccine to Control Newcastle Disease Virus Infections of Poultry in Sub-Saharan Africa.
| S-EPMC7350225 | biostudies-literature
Unknown Newcastle Disease Virus Vectored Bivalent Vaccine against Virulent Infectious Bursal Disease and Newcastle Disease of Chickens.
| S-EPMC5748598 | biostudies-literature
Unknown Recombinant Marek's Disease Virus as a Vector-Based Vaccine against Avian Leukosis Virus Subgroup J in Chicken.
| S-EPMC5127015 | biostudies-literature
Unknown Recombinant vector vaccine evolution.
| S-EPMC6668849 | biostudies-literature
Unknown Improved immunogenicity of Newcastle disease virus inactivated vaccine following DNA vaccination using Newcastle disease virus hemagglutinin-neuraminidase and fusion protein genes.
| S-EPMC4808640 | biostudies-literature