Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Ruiz A
PROVIDER: S-EPMC1150803 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Martínez-Ruiz Antonio A Villanueva Laura L González de Orduña Cecilia C López-Ferrer Daniel D Higueras María Angeles MA Tarín Carlos C Rodríguez-Crespo Ignacio I Vázquez Jesús J Lamas Santiago S
Proceedings of the National Academy of Sciences of the United States of America 20050603 24
Nitric oxide is implicated in a variety of signaling pathways in different systems, notably in endothelial cells. Some of its effects can be exerted through covalent modifications of proteins and, among these modifications, increasing attention is being paid to S-nitrosylation as a signaling mechanism. In this work, we show by a variety of methods (ozone chemiluminescence, biotin switch, and mass spectrometry) that the molecular chaperone Hsp90 is a target of S-nitrosylation and identify a susce ...[more]