Ontology highlight
ABSTRACT:
SUBMITTER: Vallim MA
PROVIDER: S-EPMC1151989 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Vallim Marcelo A MA Nichols Connie B CB Fernandes Larissa L Cramer Kari L KL Alspaugh J Andrew JA
Eukaryotic cell 20050601 6
The Cryptococcus neoformans Ras1 protein serves as a central regulator for several signaling pathways. Ras1 controls the induction of the mating pheromone response cascade as well as a distinct signaling pathway that allows this pathogenic fungus to grow at human physiological temperature. To characterize elements of the Ras1-dependent high-temperature growth pathway, we performed a multicopy suppressor screen, identifying genes whose overexpression allows the ras1 mutant to grow at 37 degrees C ...[more]