Ontology highlight
ABSTRACT:
SUBMITTER: Cuadrado A
PROVIDER: S-EPMC115279 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Cuadrado Ana A Navarro-Yubero Cristina C Furneaux Henry H Kinter Jochen J Sonderegger Peter P Muñoz Alberto A
Nucleic acids research 20020501 10
Neuroserpin is an axonally secreted serine protease inhibitor expressed in the nervous system that protects neurons from ischemia-induced apoptosis. Mutant neuroserpin forms have been found polymerized in inclusion bodies in a familial autosomal encephalopathy causing dementia, or associated with epilepsy. Regulation of neuroserpin expression is mostly unknown. Here we demonstrate that neuroserpin mRNA and the RNA-binding protein HuD are co-expressed in the rat central nervous system, and that H ...[more]