Ontology highlight
ABSTRACT:
SUBMITTER: Kinch LN
PROVIDER: S-EPMC1157100 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Kinch Lisa N LN Ginalski Krzysztof K Rychlewski Leszek L Grishin Nick V NV
Nucleic acids research 20050622 11
Restriction endonucleases and other nucleic acid cleaving enzymes form a large and extremely diverse superfamily that display little sequence similarity despite retaining a common core fold responsible for cleavage. The lack of significant sequence similarity between protein families makes homology inference a challenging task and hinders new family identification with traditional sequence-based approaches. Using the consensus fold recognition method Meta-BASIC that combines sequence profiles wi ...[more]