Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Bernal D
PROVIDER: S-EPMC1165406 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
García-Bernal David D Wright Natalia N Sotillo-Mallo Elena E Nombela-Arrieta César C Stein Jens V JV Bustelo Xosé R XR Teixidó Joaquin J
Molecular biology of the cell 20050504 7
The chemokine CXCL12 promotes T lymphocyte adhesion mediated by the integrin alpha4beta1. CXCL12 activates the GTPase Rac, as well as Vav1, a guanine-nucleotide exchange factor for Rac, concomitant with up-regulation of alpha4beta1-dependent adhesion. Inhibition of CXCL12-promoted Rac and Vav1 activation by transfection of dominant negative Rac or Vav1 forms, or by transfection of their siRNA, remarkably impaired the increase in T lymphocyte attachment to alpha4beta1 ligands in response to this ...[more]