Ontology highlight
ABSTRACT:
SUBMITTER: Fournier AK
PROVIDER: S-EPMC2662746 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Fournier Alaina K AK Campbell Latoya E LE Castagnino Paola P Liu Wendy F WF Chung Betty M BM Weaver Valerie M VM Chen Christopher S CS Assoian Richard K RK
Journal of cell science 20080101 Pt 2
Integrin-mediated adhesion to substratum is required for cyclin D1 induction in mesenchymal cells, but we show here that the induction of cyclin D1 persists despite blockade of ECM-integrin signaling in MCF10A mammary epithelial cells. E-cadherin-mediated cell-cell adhesion also supports cyclin D1 induction in these cells, and the combined inhibition of both E-cadherin and integrin adhesion is required to prevent the expression of cyclin D1 mRNA and protein. Our previous studies described a pro- ...[more]