Ontology highlight
ABSTRACT:
SUBMITTER: de la Fuente H
PROVIDER: S-EPMC1165413 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
de la Fuente Hortensia H Mittelbrunn María M Sánchez-Martín Lorena L Vicente-Manzanares Miguel M Lamana Amalia A Pardi Ruggero R Cabañas Carlos C Sánchez-Madrid Francisco F
Molecular biology of the cell 20050504 7
Initial adhesive contacts between T lymphocytes and dendritic cells (DCs) facilitate recognition of peptide-MHC complexes by the TCR. In this report, we studied the dynamic behavior of adhesion and Ag receptors on DCs during initial contacts with T-cells. Adhesion molecules LFA-1- and ICAM-1,3-GFP as well as MHC class II-GFP molecules were very rapidly concentrated at the DC contact area. Binding of ICAM-3, and ICAM-1 to a lesser extent, to LFA-1 expressed by mature but not immature DC, induced ...[more]