Ontology highlight
ABSTRACT:
SUBMITTER: Gorrini C
PROVIDER: S-EPMC1166589 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Gorrini Chiara C Loreni Fabrizio F Gandin Valentina V Sala Leonardo A LA Sonenberg Nahum N Marchisio Pier Carlo PC Biffo Stefano S
Proceedings of the National Academy of Sciences of the United States of America 20050616 26
Fibronectin (FN) is a major matrix protein involved in multiple processes. Little is known about how adhesion to FN affects the translational machinery. We show that in fibroblasts adhesion to FN triggers translation through the coordinated regulation of eukaryotic initiation factors (eIFs) 4F and 2 and is impaired by blocking beta1 integrin engagement. FN-stimulated translation has unique properties: (i) it is highly sensitive to the inhibition of phosphatidylinositol 3-kinase (PI3K), but not t ...[more]