Ontology highlight
ABSTRACT:
SUBMITTER: Kang HC
PROVIDER: S-EPMC1168829 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Kang Ho Chul HC Chae Ji Hyung JH Lee Yeon Ho YH Park Mi-Ae MA Shin June Ho JH Kim Sung-Hyun SH Ye Sang-Kyu SK Cho Yoon Shin YS Fiering Steven S Kim Chul Geun CG
Molecular and cellular biology 20050701 14
We previously demonstrated that ubiquitously expressed CP2c exerts potent erythroid-specific transactivation of alpha-globin through an unknown mechanism. This mechanism is reported here to involve specific CP2 splice variants and protein inhibitor of activated STAT1 (PIAS1). We identify a novel murine splice isoform of CP2, CP2b, which is identical to CP2a except that it has an additional 36 amino acids encoded by an extra exon. CP2b has an erythroid cell-specific transcriptional activation dom ...[more]