Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez P
PROVIDER: S-EPMC1173143 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Rodriguez Patrick P Bonte Edgar E Krijgsveld Jeroen J Kolodziej Katarzyna E KE Guyot Boris B Heck Albert J R AJ Vyas Paresh P de Boer Ernie E Grosveld Frank F Strouboulis John J
The EMBO journal 20050526 13
GATA-1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and mast cell lineages. It acts as an activator and repressor of different target genes, for example, in erythroid cells it represses cell proliferation and early hematopoietic genes while activating erythroid genes, yet it is not clear how both of these functions are mediated. Using a biotinylation tagging/proteomics approach in erythroid cells, we describe distinct GATA-1 interactions with the essential hemat ...[more]