Ontology highlight
ABSTRACT:
SUBMITTER: Miccio A
PROVIDER: S-EPMC2824460 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Miccio Annarita A Wang Yuhuan Y Hong Wei W Gregory Gregory D GD Wang Hongxin H Yu Xiang X Choi John K JK Shelat Suresh S Tong Wei W Poncz Mortimer M Blobel Gerd A GA
The EMBO journal 20091119 2
GATA transcription factors interact with FOG proteins to regulate tissue development by activating and repressing transcription. FOG-1 (ZFPM1), a co-factor for the haematopoietic factor GATA-1, binds to the NuRD co-repressor complex through a conserved N-terminal motif. Surprisingly, we detected NuRD components at both repressed and active GATA-1/FOG-1 target genes in vivo. In addition, while NuRD is required for transcriptional repression in certain contexts, we show a direct requirement of NuR ...[more]