Ontology highlight
ABSTRACT:
SUBMITTER: Nazor KE
PROVIDER: S-EPMC1173157 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Nazor Karah E KE Kuhn Franziska F Seward Tanya T Green Mike M Zwald Daniel D Pürro Mario M Schmid Jaqueline J Biffiger Karin K Power Aisling M AM Oesch Bruno B Raeber Alex J AJ Telling Glenn C GC
The EMBO journal 20050616 13
The absence of infectivity-associated, protease-resistant prion protein (PrP(Sc)) in the brains of spontaneously sick transgenic (Tg) mice overexpressing PrP linked to Gerstmann-Sträussler Scheinker syndrome, and the failure of gene-targeted mice expressing such PrP to develop disease spontaneously, challenged the concept that mutant PrP expression led to spontaneous prion production. Here, we demonstrate that disease in overexpressor Tg mice is associated with accumulation of protease-sensitive ...[more]