Ontology highlight
ABSTRACT:
SUBMITTER: Touchon M
PROVIDER: S-EPMC1174978 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Touchon Marie M Nicolay Samuel S Audit Benjamin B Brodie of Brodie Edward-Benedict EB d'Aubenton-Carafa Yves Y Arneodo Alain A Thermes Claude C
Proceedings of the National Academy of Sciences of the United States of America 20050628 28
In the course of evolution, mutations do not affect both strands of genomic DNA equally. This imbalance mainly results from asymmetric DNA mutation and repair processes associated with replication and transcription. In prokaryotes, prevalence of G over C and T over A is frequently observed in the leading strand. The sign of the resulting TA and GC skews changes abruptly when crossing replication-origin and termination sites, producing characteristic step-like transitions. In mammals, transcripti ...[more]