Ontology highlight
ABSTRACT:
SUBMITTER: Prikrylova T
PROVIDER: S-EPMC6667497 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Prikrylova Terezia T Robertson Julia J Ferrucci Francesca F Konorska Dorota D Aanes Håvard H Manaf Adeel A Zhang Beibei B Vågbø Cathrine Broberg CB Kuśnierczyk Anna A Gilljam Karin M KM Løvkvam-Køster Caroline C Otterlei Marit M Dahl John Arne JA Enserink Jorrit J Klungland Arne A Robertson Adam B AB
Scientific reports 20190730 1
In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In lower eukaryotes, replication is initiated from a defined consensus sequence, whereas a consensus sequence delineating mammalian origin of replication has not been identified. Here we show that 5-hydroxymethylcytosine (5hmC) is present at mammalian replication origins. Our data support ...[more]