Ontology highlight
ABSTRACT:
SUBMITTER: Hughes JR
PROVIDER: S-EPMC1174996 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Hughes Jim R JR Cheng Jan-Fang JF Ventress Nicki N Prabhakar Shyam S Clark Kevin K Anguita Eduardo E De Gobbi Marco M de Jong Pieter P Rubin Eddy E Higgs Douglas R DR
Proceedings of the National Academy of Sciences of the United States of America 20050705 28
An important step toward improving the annotation of the human genome is to identify cis-acting regulatory elements from primary DNA sequence. One approach is to compare sequences from multiple, divergent species. This approach distinguishes multispecies conserved sequences (MCS) in noncoding regions from more rapidly evolving neutral DNA. Here, we have analyzed a region of approximately 238kb containing the human alpha globin cluster that was sequenced and/or annotated across the syntenic regio ...[more]