Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome.
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ABSTRACT: Motivation
It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon.Results
To evaluate this possibility, we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome. We identified numerous such colocated boundary and enhancer elements from human CD4(+) T cells. We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4(+) T cells.
SUBMITTER: Jjingo D
PROVIDER: S-EPMC5994936 | biostudies-literature |
REPOSITORIES: biostudies-literature
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