Ontology highlight
ABSTRACT:
SUBMITTER: Kamiuchi S
PROVIDER: S-EPMC117539 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
Kamiuchi Shinya S Saijo Masafumi M Citterio Elisabetta E de Jager Martijn M Hoeijmakers Jan H J JH Tanaka Kiyoji K
Proceedings of the National Academy of Sciences of the United States of America 20020101 1
Transcription-coupled repair (TCR) efficiently removes a variety of lesions from the transcribed strand of active genes. By allowing rapid resumption of RNA synthesis, the process is of major importance for cellular resistance to transcription-blocking genotoxic damage. Mutations in the Cockayne syndrome group A or B (CSA or CSB) gene result in defective TCR. However, the exact mechanism of TCR in mammalian cells remains to be elucidated. We found that CSA protein is rapidly translocated to the ...[more]