Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions.
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ABSTRACT:
SUBMITTER: Mortier E
PROVIDER: S-EPMC1176451 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Publications
Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions.
Mortier Eva E Wuytens Gunther G Leenaerts Iris I Hannes Femke F Heung Man Y MY Degeest Gisèle G David Guido G Zimmermann Pascale P
The EMBO journal 20050616 14
PDZ (Postsynaptic density protein, Disc large, Zona occludens) domains are protein-protein interaction modules that predominate in submembranous scaffolding proteins. Recently, we showed that the PDZ domains of syntenin-1 also interact with phosphatidylinositol 4,5-bisphosphate (PIP2) and that this interaction controls the recruitment of the protein to the plasma membrane. Here we evaluate the general importance of PIP2-PDZ domain interactions. We report that most PDZ proteins bind weakly to PIP ...[more]
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