Predicting PDZ domain-peptide interactions from primary sequences.
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ABSTRACT:
SUBMITTER: Chen JR
PROVIDER: S-EPMC2655215 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Predicting PDZ domain-peptide interactions from primary sequences.
Chen Jiunn R JR Chang Bryan H BH Allen John E JE Stiffler Michael A MA MacBeath Gavin G
Nature biotechnology 20080901 9
PDZ domains constitute one of the largest families of interaction domains and function by binding the C termini of their target proteins. Using Bayesian estimation, we constructed a three-dimensional extension of a position-specific scoring matrix that predicts to which peptides a PDZ domain will bind, given the primary sequences of the PDZ domain and the peptides. The model, which was trained using interaction data from 82 PDZ domains and 93 peptides encoded in the mouse genome, successfully pr ...[more]
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