A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study.
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ABSTRACT:
SUBMITTER: Schick JH
PROVIDER: S-EPMC1180302 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
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A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study.
Schick James H JH Iyengar Sudha K SK Klein Barbara E BE Klein Ronald R Reading Karlie K Liptak Rachel R Millard Christopher C Lee Kristine E KE Tomany Sandra C SC Moore Emily L EL Fijal Bonnie A BA Elston Robert C RC
American journal of human genetics 20030424 6
Age-related maculopathy (ARM) is a leading cause of visual impairment among the elderly in Western populations. To identify ARM-susceptibility loci, we genotyped a subset of subjects from the Beaver Dam (WI) Eye Study and performed a model-free genomewide linkage analysis for markers linked to a quantitative measure of ARM. We initially genotyped 345 autosomal markers in 325 individuals (N=263 sib pairs) from 102 pedigrees. Ten regions suggestive of linkage with ARM were observed on chromosomes ...[more]
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