Ontology highlight
ABSTRACT:
SUBMITTER: Tan YJ
PROVIDER: S-EPMC1181587 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Tan Yee-Joo YJ Tham Puay-Yoke PY Chan Daphne Z L DZ Chou Chih-Fong CF Shen Shuo S Fielding Burtram C BC Tan Timothy H P TH Lim Seng Gee SG Hong Wanjin W
Journal of virology 20050801 15
Here we analyzed the gene expression profile of cells that stably express the severe acute respiratory syndrome coronavirus (SARS-CoV) 3a protein to determine its effects on host functions. A lung epithelial cell-line, A549, was chosen for this study because the lung is the primary organ infected by SARS-CoV and fatalities resulted mainly from pulmonary complications. Our results showed that the expression of 3a up-regulates the mRNA levels of all three subunits, Aalpha, Bbeta, and gamma, of fib ...[more]