Dataset Information

Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients.

ABSTRACT:

Background

Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations.

Methods

Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland.

Results

No association was found in any of the populations studied.

Conclusion

Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.

SUBMITTER: Clarimon J

PROVIDER: S-EPMC1183215 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature

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Publications

Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients.

Clarimon Jordi J Xiromerisiou Georgia G Eerola Johanna J Gourbali Vanesa V Hellström Olli O Dardiotis Euthimios E Peuralinna Terhi T Papadimitriou Alexandros A Hadjigeorgiou George M GM Tienari Pentti J PJ Singleton Andrew B AB

BMC neurology 20050620

<h4>Background</h4>Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations.<h4>Methods</h4>Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were ...[more]

PMID: 15967032

Similar Datasets

Project description:BackgroundThe phospholipase A2 Group 6 (PLA2G6, also known as PLA2, PARK14, and iPLA2) gene encodes a group VIA calcium-independent phospholipase A2. Genetic polymorphism of PLA2G6 has been indicated to be involved in conferring susceptibility for Parkinson's disease (PD), whereas conclusive results have not been obtained. Thus, we intended to conduct a systematic review to determine if PLA2G6 genetic variation confers a greater susceptibility to PD.MethodsAll case-control studies that investigated the association of the PLA2G6 polymorphisms with the risk of PD published before 15 July 2018 were included. The literature was comprehensively searched and identified in five English databases (EBSCO, Pubmed, OVID, EMBASE and ISI Web of Knowledge) and four Chinese databases (Wanfang database, Chinese Biomedical Literature Database, China Academic Journals Database and VIP database). We performed analyses of study characteristics, heterogeneity, and forest plot in analyses analogous to dominant, codominant and additive models with the pooled odds ratio (OR) in fixed- or random-effects models as the measure of association.ResultsA total of 664 potentially relevant studies were retrieved with the initial search, of which eight studies fulfilled the inclusion criteria, and included 2,779 PD patients and 3,291 control participants,. Among all the reported 27 genetic variants, 15 single nucleotide polymorphisms (SNPs) were present only in patients, and only five available SNPs (rs2267369, rs140758033, c.1959T>A (Gly653Gly), rs76718524, rs199935023) were pooled in the meta-analysis. However, there was no evidence for a significant association between the five SNPs and PD risk in dominant, codominant and allele models, suggesting a lack of association between PLA2G6 genetic variation and PD susceptibility.ConclusionThe present study assessed the association of PLA2G6 genetic polymorphism with the risk PD, and the result strongly demonstrates that PLA2G6 polymorphism is not associated with PD susceptibility.

Dataset Information

Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients.

Background

Methods

Results

Conclusion

Publications

Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients.

Similar Datasets

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