Ontology highlight
ABSTRACT:
SUBMITTER: Wider C
PROVIDER: S-EPMC2875476 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Wider Christian C Dachsel Justus C JC Soto Alexandra I AI Heckman Michael G MG Diehl Nancy N NN Yue Mei M Lincoln Sarah S Aasly Jan O JO Haugarvoll Kristoffer K Trojanowski John Q JQ Papapetropoulos Spiridon S Mash Deborah D Rajput Alex A Rajput Ali H AH Gibson J Mark JM Lynch Timothy T Dickson Dennis W DW Uitti Ryan J RJ Wszolek Zbigniew K ZK Farrer Matthew J MJ Ross Owen A OA
Movement disorders : official journal of the Movement Disorder Society 20090201 3
Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no ...[more]