Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC1187945 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Liu Xingkun X McLeod Ian I Anderson Scott S Yates John R JR He Xiangwei X
The EMBO journal 20050804 16
Kinetochore composition and structure are critical for understanding how kinetochores of different types perform similar functions in chromosome segregation. We used affinity purification to investigate the kinetochore composition and assembly in Schizosaccharomyces pombe. We identified a conserved DASH complex that functions to ensure precise chromosome segregation. Unlike DASH in budding yeast that is localized onto kinetochores throughout the cell cycle, SpDASH is localized onto kinetochores ...[more]