Ontology highlight
ABSTRACT:
SUBMITTER: Kikuchi K
PROVIDER: S-EPMC1190240 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Kikuchi Koji K Taniguchi Yoshihito Y Hatanaka Atsushi A Sonoda Eiichiro E Hochegger Helfrid H Adachi Noritaka N Matsuzaki Yasuo Y Koyama Hideki H van Gent Dik C DC Jasin Maria M Takeda Shunichi S
Molecular and cellular biology 20050801 16
Homologous recombination (HR) requires nuclease activities at multiple steps, but the contribution of individual nucleases to the processing of double-strand DNA ends at different stages of HR has not been clearly defined. We used chicken DT40 cells to investigate the role of flap endonuclease 1 (Fen-1) in HR. FEN-1-deficient cells exhibited a significant decrease in the efficiency of immunoglobulin gene conversion while being proficient in recombination between sister chromatids, suggesting tha ...[more]