Ontology highlight
ABSTRACT:
SUBMITTER: Chen CC
PROVIDER: S-EPMC5584059 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Chen Chun-Chin CC Avdievich Elena E Zhang Yongwei Y Zhang Yu Y Wei Kaichun K Lee Kyeryoung K Edelmann Winfried W Jasin Maria M LaRocque Jeannine R JR
DNA repair 20170710
DNA double-strand breaks (DSBs) can be repaired through several mechanisms, including homologous recombination (HR). While HR between identical sequences is robust in mammalian cells, HR between diverged sequences is suppressed by DNA mismatch-repair (MMR) components such as MSH2. Exonuclease I (EXO1) interacts with the MMR machinery and has been proposed to act downstream of the mismatch recognition proteins in mismatch correction. EXO1 has also been shown to participate in extensive DSB end re ...[more]