Ontology highlight
ABSTRACT:
SUBMITTER: Poirel L
PROVIDER: S-EPMC1195426 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Poirel Laurent L Brinas Laura L Verlinde Annemie A Ide Louis L Nordmann Patrice P
Antimicrobial agents and chemotherapy 20050901 9
Screening by a double-disk synergy test identified a Pseudomonas aeruginosa isolate that produced a clavulanic acid-inhibited expanded-spectrum beta-lactamase (ESBL). Cloning and sequencing identified a novel ESBL, BEL-1, weakly related to other Ambler class A ESBLs. beta-Lactamase BEL-1 hydrolyzed significantly most expanded-spectrum cephalosporins and aztreonam, and its activity was inhibited by clavulanic acid, tazobactam, cefoxitin, moxalactam, and imipenem. This chromosome-encoded ESBL gene ...[more]