Ontology highlight
ABSTRACT:
SUBMITTER: Clark SW
PROVIDER: S-EPMC1196314 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Clark Sean W SW Rose Mark D MD
Molecular biology of the cell 20050622 9
Arp1p is the only actin-related protein (ARP) known to form actin-like filaments. Unlike actin, Arp1p functions with microtubules, as part of the dynein regulator, dynactin. Arp1p's dissimilar functions imply interactions with a distinct set of proteins. To distinguish surface features relating to Arp1p's core functions and to identify the footprint of protein interactions essential for dynactin function, we performed the first complete charge-cluster-to-alanine scanning mutagenesis of an ARP an ...[more]