Ontology highlight
ABSTRACT:
SUBMITTER: Zhao WM
PROVIDER: S-EPMC1201590 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Zhao Wei-meng WM Fang Guowei G
Proceedings of the National Academy of Sciences of the United States of America 20050829 37
Initiation of cytokinesis requires the establishment of the cleavage plane, the assembly of the contractile ring, and the ingression of the cleavage furrow. MgcRacGAP, a GTPase-activating protein for RhoA, is required for cytokinesis, but the mechanism of its action remains unknown. We report here that MgcRacGAP is required for the assembly of anillin and myosin into the contractile ring. In addition, MgcRacGAP is required for the localized activation of myosin through the RhoA-mediated phosphor ...[more]