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Characterization of a multicopper oxidase gene from Staphylococcus aureus.


ABSTRACT: A multicopper oxidase gene from Staphylococcus aureus was cloned and overexpressed. Purified recombinant multicopper oxidase oxidized the substrate 3,3'-dimethoxybenzidine in the presence of copper. Disruption of mco showed copper sensitivity and H(2)O(2) resistance, suggesting roles for mco in copper homeostasis and oxidative stress response. Northern blot analysis showed copper-induced mco transcription.

SUBMITTER: Sitthisak S 

PROVIDER: S-EPMC1214694 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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Characterization of a multicopper oxidase gene from Staphylococcus aureus.

Sitthisak S S   Howieson K K   Amezola C C   Jayaswal R K RK  

Applied and environmental microbiology 20050901 9


A multicopper oxidase gene from Staphylococcus aureus was cloned and overexpressed. Purified recombinant multicopper oxidase oxidized the substrate 3,3'-dimethoxybenzidine in the presence of copper. Disruption of mco showed copper sensitivity and H(2)O(2) resistance, suggesting roles for mco in copper homeostasis and oxidative stress response. Northern blot analysis showed copper-induced mco transcription. ...[more]

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