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Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution.

ABSTRACT: The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.

SUBMITTER: Bushnell DA

PROVIDER: S-EPMC122170 | biostudies-literature | 2002 Feb

REPOSITORIES: biostudies-literature

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Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution.

Bushnell David A DA Cramer Patrick P Kornberg Roger D RD

Proceedings of the National Academy of Sciences of the United States of America 20020122 3

The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism. ...[more]

PMID: 11805306

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