Ontology highlight
ABSTRACT:
SUBMITTER: Sim AT
PROVIDER: S-EPMC1223558 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Sim Alistair T R AT Baldwin Monique L ML Rostas John A P JA Holst Jeff J Ludowyke Russell I RI
The Biochemical journal 20030801 Pt 3
Modulation of exocytosis is integral to the regulation of cellular signalling, and a variety of disorders (such as epilepsy, hypertension, diabetes and asthma) are closely associated with pathological modulation of exocytosis. Emerging evidence points to protein phosphatases as key regulators of exocytosis in many cells and, therefore, as potential targets for the design of novel therapies to treat these diseases. Diverse yet exquisite regulatory mechanisms have evolved to direct the specificity ...[more]