Ontology highlight
ABSTRACT:
SUBMITTER: Armen RS
PROVIDER: S-EPMC1224618 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Armen Roger S RS Bernard Brady M BM Day Ryan R Alonso Darwin O V DO Daggett Valerie V
Proceedings of the National Academy of Sciences of the United States of America 20050912 38
Several neurodegenerative diseases are linked to expanded repeats of glutamine residues, which lead to the formation of amyloid fibrils and neuronal death. The length of the repeats correlates with the onset of Huntington's disease, such that healthy individuals have <38 residues and individuals with >38 repeats exhibit symptoms. Because it is difficult to obtain atomic-resolution structural information for poly(l-glutamine) (polyQ) in aqueous solution experimentally, we performed molecular dyna ...[more]