HiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.
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ABSTRACT:
SUBMITTER: Rivetti di Val Cervo P
PROVIDER: S-EPMC7928200 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.
Rivetti di Val Cervo Pia P Besusso Dario D Conforti Paola P Cattaneo Elena E
Nature reviews. Neurology 20210303 6
Human induced pluripotent stem cells (hiPSCs) were first generated in 2007, but the full translational potential of this valuable tool has yet to be realized. The potential applications of hiPSCs are especially relevant to neurology, as brain cells from patients are rarely available for research. hiPSCs from individuals with neuropsychiatric or neurodegenerative diseases have facilitated biological and multi-omics studies as well as large-scale screening of chemical libraries. However, researche ...[more]
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