Ontology highlight
ABSTRACT:
SUBMITTER: McCarty JH
PROVIDER: S-EPMC1224645 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
McCarty Joseph H JH Cook Aaron A AA Hynes Richard O RO
Proceedings of the National Academy of Sciences of the United States of America 20050912 38
alphavbeta8 Integrin is highly expressed in the vertebrate CNS, and mice lacking the alphav or beta8 genes develop cerebral hemorrhage due to defective interactions between blood vessels and alphavbeta8-expressing neural cells. Although alphavbeta8 binds many of the same extracellular matrix protein ligands as other integrins, very little is known about the intracellular signal transduction events used by alphavbeta8 to regulate CNS development. Here we identify Band 4.1B as an intracellular fac ...[more]