Ontology highlight
ABSTRACT:
SUBMITTER: Harakuni T
PROVIDER: S-EPMC1231140 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Harakuni Tetsuya T Sugawa Hideki H Komesu Ai A Tadano Masayuki M Arakawa Takeshi T
Infection and immunity 20050901 9
Noninvasive mucosal vaccines are attractive alternatives to parenteral vaccines. Although the conjugation of vaccine antigens with the B subunit of cholera toxin (CTB) is one of the most promising strategies for vaccine delivery to mucosal immune systems, the molecule cannot tolerate large-protein fusion, as it severely impairs pentamerization and loses affinity for GM1-ganglioside. Here we report a new strategy, in which steric hindrance between CTB-antigen fusion subunits is significantly redu ...[more]