Ontology highlight
ABSTRACT:
SUBMITTER: Basile AS
PROVIDER: S-EPMC123277 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Basile Anthony S AS Fedorova Irina I Zapata Agustin A Liu Xiaoguang X Shippenberg Toni T Duttaroy Alokesh A Yamada Masahisa M Wess Jurgen J
Proceedings of the National Academy of Sciences of the United States of America 20020801 17
Little is known about the physiological roles of the M5 muscarinic receptor, the last member of the muscarinic receptor family (M1-M5) to be cloned. In the brain, the M5 receptor subtype is preferentially expressed by dopaminergic neurons of the substantia nigra and the ventral tegmental area. Dopaminergic neurons located in the ventral tegmental area are known to play important roles in mediating both the rewarding effects of opiates and other drugs of abuse and the manifestations of opiate/dru ...[more]