Ontology highlight
ABSTRACT:
SUBMITTER: Patel M
PROVIDER: S-EPMC1234927 | biostudies-literature | 2001 Jan
REPOSITORIES: biostudies-literature
Patel M M Dorman K S KS Zhang Y H YH Huang B L BL Arnold A P AP Sinsheimer J S JS Vilain E E McCabe E R ER
American journal of human genetics 20001207 1
The molecular evolution of DAX1, SRY, and SOX9, genes involved in mammalian sex determination, was examined in six primate species. DAX1 and SRY have been added to the X and Y chromosomes, respectively, during mammalian evolution, whereas SOX9 remains autosomal. We determined the genomic sequences of DAX1, SRY, and SOX9 in all six species, and calculated K(a), the number of nonsynonymous substitutions per nonsynonymous site, and compared this with the K(s), the number of synonymous substitutions ...[more]